Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial

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Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial

BACKGROUND The use of nicotine replacement therapy before quitting smoking is called nicotine preloading. Standard smoking cessation protocols suggest commencing nicotine replacement therapy only on the first day of quitting smoking (quit day) aiming to reduce withdrawal symptoms and craving. However, other, more successful smoking cessation pharmacotherapies are used prior to the quit day as w...

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BACKGROUND Nicotine replacement therapy is an effective treatment for nicotine-dependent smokers. However, cessation rates are modest, and preliminary studies suggest that combination therapy may be superior. We compared the efficacy of the nicotine inhaler plus nicotine patch vs nicotine inhaler plus placebo patch for smoking cessation. METHODS A double-blind, randomized, placebo-controlled ...

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Flexible, dual-form nicotine replacement therapy or varenicline in comparison with nicotine patch for smoking cessation: a randomized controlled trial

BACKGROUND Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replacement therapy (NRT+), or varenicline (VR). METHODS A total of 737 smokers, inc...

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ژورنال

عنوان ژورنال: Trials

سال: 2014

ISSN: 1745-6215

DOI: 10.1186/1745-6215-15-296